Spike-specific IgG secretion

1. Spermidine increases spike-specific IgG secretion in humans.

   “Spermidine reversed these features and significantly enhanced spike-specific IgG secretion, memory B cell recall responses and neutralising antibody activity, specifically in non-responders.”

   Human trialin vaccine non-responders6 mg daily13 weeksn = 40

   Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults-A Pilot Study

   Aging cell·May 22, 2026

More on Spermidine