SPChigh AT2 cells

Age is associated with SPChigh AT2 cells in humans.

“Among alveolar epithelial cells, aging is associated with a decreased relative proportion of surfactant-expressing SPChigh AT2 cells.”

Humansin alveolar epithelial cellslung

Single-cell atlas of human lung aging identifies cell type dyssynchrony and increased transcriptional entropy

Nature communications·22 Jan 2026