Somatic second hit

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  • Humans1

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bioRxiv

Young adults’ tumours carried fewer acquired DNA changes

An observational study compared genomes from 698 people aged 18–39 and 5,220 older adults; their tumours largely shared the same cancer-driving genetic changes.An observational study compared genomes from 698 people aged 18–39 and 5,220 older adults; their tumours largely shared the same cancer-driving genetic changes.

Preprint: cross-sectional study of 698 adolescents and young adults with cancer, against older adultsMechanisms

Limit: Age-dependent cancer subtypes could explain some apparent age differences in tumour genomes