Somatic variant burden

Biomarker

1 paper1 finding

  • Humans1

Associations

1

Adolescent and young adult age

downin humans1

1 study
  1. Adolescent and young adult age is associated with somatic variant burden in humans.

    “AYA tumors carried fewer somatic variants yet largely shared the same genetic drivers”

    Humanssolid cancerstumor

    Young adults’ tumours carried fewer acquired DNA changes

    bioRxiv16 Oct 2026Preprint

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bioRxiv

Young adults’ tumours carried fewer acquired DNA changes

An observational study compared genomes from 698 people aged 18–39 and 5,220 older adults; their tumours largely shared the same cancer-driving genetic changes.An observational study compared genomes from 698 people aged 18–39 and 5,220 older adults; their tumours largely shared the same cancer-driving genetic changes.

Preprint: cross-sectional study of 698 adolescents and young adults with cancer, against older adultsMechanisms

Limit: Age-dependent cancer subtypes could explain some apparent age differences in tumour genomes