Colibactin-associated mutational signature prevalence

Biomarker

1 paper1 finding

  • Humans1

Associations

1

Adolescent and young adult age

upin humans1

1 study
  1. Adolescent and young adult age is associated with colibactin-associated mutational signature prevalence in humans.

    “Colibactin, APOBEC and homologous recombination deficiency-associated signatures were more prevalent in AYA colorectal, gynecological and breast cancers, respectively”

    Humanscolorectal cancertumor

    Young adults’ tumours carried fewer acquired DNA changes

    bioRxiv16 Oct 2026Preprint

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 11 in 12 months
bioRxiv

Young adults’ tumours carried fewer acquired DNA changes

An observational study compared genomes from 698 people aged 18–39 and 5,220 older adults; their tumours largely shared the same cancer-driving genetic changes.An observational study compared genomes from 698 people aged 18–39 and 5,220 older adults; their tumours largely shared the same cancer-driving genetic changes.

Preprint: cross-sectional study of 698 adolescents and young adults with cancer, against older adultsMechanisms

Limit: Age-dependent cancer subtypes could explain some apparent age differences in tumour genomes