Small, rare, predominantly loss-type somatic copy-number alterations

Chronological age is associated with small, rare, predominantly loss-type somatic copy-number alterations in humans.

“Small (<1 Mb), rare, predominantly loss-type CNAs accumulated progressively and stochastically with age.”

Humanshealthy donorslymphocyten = 16

Somatic copy-number alteration signatures reveal sex-divergent aging trajectories accelerated in cancer

bioRxiv (Cold Spring Harbor Laboratory)·23 May 2026Preprint