Sex-chromosome loss cells

Chronological age is associated with sex-chromosome loss cells in humans (X-loss cells: +0.10 percentage points/year; Y-loss cells: +0.03 percentage points/year).

“chromosome X loss cells in females accumulated at +0.10 percentage points per year, versus +0.03 for chromosome Y loss cells in males.”

Humansfemale chromosome X loss versus male chromosome Y losslymphocyten = 16

Somatic copy-number alteration signatures reveal sex-divergent aging trajectories accelerated in cancer

bioRxiv (Cold Spring Harbor Laboratory)·23 May 2026Preprint