CNA-based biological age

1. Esophageal adenocarcinoma is associated with CNA-based biological age in humans.

   “Applied to a matched esophageal cohort, the clock detected accelerated aging from normal squamous epithelium through Barrett’s esophagus to esophageal adenocarcinoma”

   Humansmatched esophageal cohort; normal squamous epithelium through Barrett’s esophagus to esophageal adenocarcinomaesophageal epithelium

   Somatic copy-number alteration signatures reveal sex-divergent aging trajectories accelerated in cancer

   bioRxiv (Cold Spring Harbor Laboratory)·23 May 2026Preprint

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