Autosomal single-nucleotide variant burden

1. Sex-chromosome loss is associated with autosomal single-nucleotide variant burden in humans.

   “in younger donors, loss cells carried fewer autosomal SNVs than non-loss cells, whereas in older donors (>30 years), loss cells exceeded non-loss cells in both sexes.”

   Humanssex-chromosome loss cells compared with non-loss cellslymphocyte

   Somatic copy-number alteration signatures reveal sex-divergent aging trajectories accelerated in cancer

   bioRxiv (Cold Spring Harbor Laboratory)·23 May 2026Preprint

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