Research Square
Method measures metabolic rates in mouse liver and muscle
In mouse experiments, a low-dose tracer method measured carbon flow through multiple chemical pathways and detected changes that standard labeling analysis missed.In mouse experiments, a low-dose tracer method measured carbon flow through multiple chemical pathways and detected changes that standard labeling analysis missed.
![Schematic overview and validation of the in vivo [13C6]glucose tracing platform for hepatic carbon flux analysis under ad libitum and fasting conditions (a) Workflow of the 120-min primed-continuous…](/_next/image?url=%2Ffig%2FPPR-PPR1359390%2F4ec329b2.webp&w=1600&q=75&dpl=13fbe8f64a08)
Preprint: mouse studyLipid and ceramide metabolism
Who was studiedMice
What changedThe tracer method detected small changes in metabolic rates that standard labeling analysis missed
The catchMetabolic rates outside steady-state conditions were not measured