SII

1. SII mediates AIP in humans (10.5% mediated).

   “SII statistically accounted for 7.3 and 10.5% of the observed associations for HOMA-IR and AIP, respectively.”

   HumansNHANES 2005-2020n = 15,314

   Diet quality assessed by healthy eating index and its association with metabolic aging: mediation by systemic immune-inflammation index

   Frontiers in nutrition·May 28, 2026

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1. SII mediates HOMA-IR in humans (7.3% mediated).

   “SII statistically accounted for 7.3 and 10.5% of the observed associations for HOMA-IR and AIP, respectively.”

   HumansNHANES 2005-2020n = 15,314

   Diet quality assessed by healthy eating index and its association with metabolic aging: mediation by systemic immune-inflammation index

   Frontiers in nutrition·May 28, 2026

More on HOMA-IR

1. SII is associated with sarcopenia in humans.

   “Multivariable regression confirmed positive associations for SII, SIRI, NLR, PIV, NPAR, NLPR, and an inverse association for ALI (all P < 0.05).”

   Humansin patients with type 2 diabetes mellitus

   Evaluation of ten composite inflammatory indicators for sarcopenia in type 2 diabetes mellitus

   Frontiers in endocrinology·Aug 28, 2026

More on Sarcopenia