2 papers1 finding
Mortality
no changein humans1
Sex steroids have no effect on mortality in humans.
“In fully adjusted models, no association was seen between SHBG and MACE, or between any hormone or SHBG and all-cause mortality.”
Humansfully adjusted modelserummedian 4.6 yearsfemalesn = 5,535
The lancet. Healthy longevity7 Feb 2022
National Institute of Diabetes and Digestive and Kidney DiseasesUS$926.5k
An observational study of 353 adults aged 36–87 linked distinct brain patterns to later depression in younger women and blood markers of brain deterioration in older men.An observational study of 353 adults aged 36–87 linked distinct brain patterns to later depression in younger women and blood markers of brain deterioration in older men.
In 137 aging adults tracked across one year, changes in estradiol and testosterone showed opposing associations with cerebellar subregion volumes in men and women.In 137 aging adults tracked across one year, changes in estradiol and testosterone showed opposing associations with cerebellar subregion volumes in men and women.
In 5,535 women aged 70 and older, endogenous oestradiol concentrations showed no association with major cardiovascular events or all-cause mortality over 4.5 years of…In 5,535 women aged 70 and older, endogenous oestradiol concentrations showed no association with major cardiovascular events or all-cause mortality over 4.5 years of follow-up.