Senescent T cells
Biomarker1 paper1 finding
- Humans1
Associations
1Thymus grade
downin humans1
1 study
Thymus grade
downin humans1
Thymus grade is associated with senescent T cells in humans.
Humansamong PWHn = 654
Thymic Involution and Function in People With HIV and General Population Controls: A Cross-Sectional Analysis From Two Danish Cohort Studies · Aging cell · 23 Sep 2026
Latest
49Sestrin1 protects aging livers and aids exercise in mice
In aged mice, lacking Sestrin1 worsened liver cell senescence and fat buildup, and the protein proved indispensable for the liver benefits of…In aged mice, lacking Sestrin1 worsened liver cell senescence and fat buildup, and the protein proved indispensable for the liver benefits of exercise.
Exercise or drugs improved heart function in aging mice
A nine-month randomised experiment in 12-month-old mice compared exercise (11 mice), two drugs (15), both (16) and natural aging (12); the…A nine-month randomised experiment in 12-month-old mice compared exercise (11 mice), two drugs (15), both (16) and natural aging (12); the interventions improved heart performance.
Acetate reduced flu virus multiplication in human lung cells
In human lung cells that had stopped dividing, laboratory experiments found that acetate also reduced inflammatory responses.In human lung cells that had stopped dividing, laboratory experiments found that acetate also reduced inflammatory responses.
Astrocyte Structure-Function Relationship in Senescence and Neurodegeneration
Immunosenescence in tumor progression: from synergistic mechanisms to therapeutic strategies
Melissic acid reduces senescence in human stem cells via cAMP signaling
A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular…A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.
Senescent CD4 T cells drive age-associated autoimmunity in mice and humans
Targeting senescent immune cells with fisetin or ruxolitinib reduced disease features and protected mice against autoimmune peripheral nerve damage.Targeting senescent immune cells with fisetin or ruxolitinib reduced disease features and protected mice against autoimmune peripheral nerve damage.
Senescent prostate cancer cells drive stromal remodeling through TGF-beta signaling
Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment…Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment can blunt.