Senescent-cell accumulation within organs

1. Senescent cell accumulation is associated with senescent-cell accumulation within organs in mice.

   “Importantly, senescence accumulation was strongly coordinated within organs but showed little correlation across them, supporting the idea of a tissue specific progression of ageing.”

   AnimalsStrong coordination within organs, but little correlation across organsmultiple organs

   Single-cell quantification of senescence burden reveals cell type-specific ageing dynamics across organs

   bioRxiv (Cold Spring Harbor Laboratory)·14 Nov 2025Preprint

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