Transcriptomic senescence signatures

Senescent cells are associated with transcriptomic senescence signatures in cells.

“The cells we identify as senescent displayed transcriptomic senescence signatures, providing a direct molecular link between protein- and mRNA-level detection of senescence.”

CellsCells identified as senescent using protein-level markers

Single-cell quantification of senescence burden reveals cell type-specific ageing dynamics across organs

bioRxiv (Cold Spring Harbor Laboratory)·14 Nov 2025Preprint