Senescence load

Biomarker

1 paper studies it8 more mention it1 finding

  • Animals1

Interventions

1

Canagliflozin

downin mice1

1 study
  1. Canagliflozin decreases senescence load in mice.

    “short-term treatment with the SGLT2 inhibitor canagliflozin reduced the senescence load in visceral adipose tissue”

    Animalsin dietary obesityvisceral adipose tissueshort-term

    SGLT2 inhibition eliminates senescent cells and alleviates pathological aging

    Nature aging

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Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 1Oct 2026: 01 paper in 12 months
bioRxiv

Mechanistic biological age clock matches PhenoAge in predicting human mortality

The systems pharmacology model splits biological age into organ axes, revealing that pharmacological drops in inflammation may not translate to expected risk reductions.The systems pharmacology model splits biological age into organ axes, revealing that pharmacological drops in inflammation may not translate to expected risk reductions.

Preprint: cohort study of 24,650 peoplePhenoAge