Senescence-associated endogenous retrovirus-derived double-stranded RNA

1. Senescence-associated endogenous retrovirus-derived double-stranded RNA activates type I interferon signalling in human cells.

   “double-stranded RNAs (dsRNAs), which activate the RIG-I/MDA5-MAVS signaling pathway and trigger a type I interferon (IFN-I) response in senescent fibroblasts.”

   Cellssenescent fibroblasts; through RIG-I/MDA5-MAVS signalingfibroblast

   Reactivation of senescence-associated endogenous retroviruses by ATF3 drives interferon signaling in aging

   Nature aging·14 Nov 2024

More on Type I interferon signalling

1. ATF3 increases senescence-associated endogenous retrovirus-derived double-stranded RNA in human cells.

   “These SA-ERVs can be bidirectional transcriptionally activated by activating transcription factor 3 (ATF3) to generate double-stranded RNAs (dsRNAs)”

   Cellssenescent cellsfibroblast

   Reactivation of senescence-associated endogenous retroviruses by ATF3 drives interferon signaling in aging

   Nature aging·14 Nov 2024

More on ATF3

1. Older age is associated with senescence-associated endogenous retrovirus-derived double-stranded RNA in humans.

   “we observed an accumulation of dsRNAs derived from SA-ERVs and higher levels of IFNβ in blood of aged individuals.”

   Humansblood

   Reactivation of senescence-associated endogenous retroviruses by ATF3 drives interferon signaling in aging

   Nature aging·14 Nov 2024