Senescence-associated beta-galactosidase staining

1. Doxorubicin increases senescence-associated beta-galactosidase staining in rat cells.

   “In DOX-treated neonatal cardiomyocytes, increased positive staining for senescence-associated beta-galactosidase, cdk-I expression, decreased cardiac troponin I phosphorylation, and decreased telomerase activity were observed”

   Cellsneonatal cardiomyocytesheart10(-7) mol L(-1)

   Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage

   Aging cell·21 Nov 2007

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1. TERT decreases senescence-associated beta-galactosidase staining in human cells.

   “telomerase-expressing clones had elongated telomeres, divided vigorously, and showed reduced straining for beta-galactosidase, a biomarker for senescence.”

   Cellstelomerase-expressing clones compared with telomerase-negative control clonesretinal pigment epithelial cells and foreskin fibroblasts

   Extension of life-span by introduction of telomerase into normal human cells

   Science (New York, N.Y.)·16 Jan 1998

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