SAM/SAH ratio

1. Growth hormone increases SAM/SAH ratio in mice.

   “SAM:SAH ratios were markedly higher in GH Tg mice.”

   Animalsin GH Tg mice compared to wild-type mice8 weeks

   Metabolic adaptation of short-living growth hormone transgenic mice to methionine restriction and supplementation

   Annals of the New York Academy of Sciences·1 Apr 2018

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1. fmo-2 decreases SAM/SAH ratio in worms.

   “This modified flux results in a decrease in the ratio of S-adenosyl-methionine (SAM) to S-adenosyl-homocysteine (SAH), consequently diminishing methylation capacity.”

   Reviewmodified one-carbon metabolic flux during fmo-2 overexpression

   Flavin-containing monooxygenase (FMO): Beyond xenobiotics

   BioEssays : news and reviews in molecular, cellular and developmental biology·7 May 2024

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