Cell Metabolism · Nov 3, 2026

Fueling the failing heart: SGLT2i directly activates the hidden PANK1

By Deng C, Tang X

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are rising stars for treating heart failure as first-line drugs, but the mechanism remains elusive. In a recent issue of Science, Forelli and colleagues show that SGLT2i bind directly to cardiac pantothenate kinase 1, boosting coenzyme A biosynthesis to support energy metabolism and functional recovery.

doi.org/10.1016/j.cmet.2026.09.007PubMed 42976771Interventions