Regional cortical thickness

Biomarker

2 papers2 findings

Humans2

Associations

Cognitive function

upin humans1

1 study

Cognitive function is associated with regional cortical thickness in humans.
“Elevated cognitive performance was cross-sectionally associated with increased regional cortical thickness and effects were most prominent in mid-life compared to later ages.”
HumansGenerally healthy, typically aging participantscerebral cortex
Structural Brain Indicators of Cognitive Performance in Middle and Late Adulthood: The Human Connectome Project in Aging/Aging Adult Brain Connectome Cohort
bioRxiv (Cold Spring Harbor Laboratory)22 Jan 2026Preprint

Epigenetic age

downin humans1

1 study

Epigenetic age is associated with regional cortical thickness in humans.
“We observed an association of epigenetic age acceleration with cortical thinning across almost all cortical regions”
HumansGeneral-population and depression cohortscerebral cortexn = 756
Associations of epigenetic aging with cortical thickness, brain age gaps, and neuroanatomical heterogeneity
medRxiv10 Nov 2025Preprint

Latest

8 in 12 months

Geriatrics & Gerontology International1 Oct

Cortical surface areas link to fall-related fracture odds

Larger caudal anterior cingulate area linked to lower simple-fall fracture odds (OR 0.95), while larger insula area linked to higher odds (OR 1.05).Larger caudal anterior cingulate area linked to lower simple-fall fracture odds (OR 0.95), while larger insula area linked to higher odds (OR 1.05).

Mendelian randomisation in 51,000 peopleBones and joints

Paper

bioRxiv22 Jan