Pyroptosis

Biomarker1 paper

Animals1

Latest

11

MethodsReview19 h

Multimodal Technology-Driven aging Research: Decoding the Mitochondria‒Pyroptosis axis in muscle atrophy and cognitive decline

Research SquareAnimalsPreprint2 Oct

Silencing LCN2 eases postoperative cognitive deficits in mice

AAV-mediated knockdown of LCN2 in aged mice limited microglial inflammation, reduced neuronal pyroptosis, and rescued memory following surgery.AAV-mediated knockdown of LCN2 in aged mice limited microglial inflammation, reduced neuronal pyroptosis, and rescued memory following surgery.

NutrientsHuman trial15 Sep

Effects of a Combined Vitamin D₃ and Docosahexaenoic Acid Intervention on Cognitive Function and Blood Pyroptotic Biomarkers in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized, Double-Blind, Placebo-Controlled Trial

Mild cognitive impairment

American Journal of TransplantationAnimals8 Sep

NLR family pyrin domain containing 3-mediated Kupffer cell pyroptosis aggravates ischemia-reperfusion injury after aging donor liver transplantation through CD38-nicotinamide adenine dinucleotide⁺-sirtuin 1-dependent acetylation of estrogen-related receptor α

Sirtuin signalling

Frontiers in Cell and Developmental BiologyHumans6 Sep

Modified frailty index predicts programmed cell death activation and sepsis risk after total hip arthroplasty: a retrospective cohort study

Bone ResearchAnimals3 Sep

Inhibition of ERK5 activity ameliorates osteoarthritis by suppressing NLRP3 inflammasome-mediated chondrocyte pyroptosis

NLRP3 inflammasome

BiogerontologyReview31 Aug

Inflammaging and cytokine-driven cardiovascular senescence in age-related myocardial infarction: mechanisms, biomarkers, and precision immunotherapy strategies

Cellular senescence

International ImmunopharmacologyAnimals30 Aug

Targeting the macrophage-NLRP3 inflammasome-pyroptosis axis: Metformin-capped silver nanoparticles as a novel therapy for premature ovarian insufficiency

Reproductive system

BiomoleculesReview27 Aug

The Role of Skeletal Muscle Mitochondria in NLRP3 Inflammasome Signaling

NLRP3 inflammasome

Biochimica et Biophysica Acta Molecular Basis of DiseaseAnimals26 Aug

Frailty exacerbates left atrial remodeling and dysfunction through activation of AIM2 and NLR inflammasome-dependent cardiomyocytes pyroptosis after myocardial infarction in aged mice

NLRP3 inflammasome