Pyramidal neuron density

1. Dementia decreases pyramidal neuron density in humans (≈ 45%).

   “Pyramidal neuron densities were lowered by ≈ 45% and volumes by ≈ 37% within all dementia groups relative to controls, except for FTD densities.”

   Humansall dementia groups relative to controls, except for FTD densitiesmedial prefrontal cortex layers III and V

   High vulnerability of medial prefrontal pyramidal neurons in post-stroke, vascular, Alzheimer's disease, and aging-related dementias

   Alzheimer's & dementia : the journal of the Alzheimer's Association·1 Feb 2026

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