Protein score is linked with type 2 diabetes incidence in humans (Mediation of associations between air pollutant exposures and type 2 diabetes) (Proportions mediated: PM2.5 31.69%; NO2 18.06%; NOx 16.81%; SO2 19.71%).
“The protein score mediated 31.69% (PM2.5), 18.06% (NO2), 16.81% (NOx), and 19.71% (SO2) of the associations.”
HumansMediation of associations between air pollutant exposures and type 2 diabetesplasma13.64 yearsn = 44,917
A blood-protein score statistically accounted for 31.69% of the association between fine-particle pollution and type 2 diabetes in a cohort of 44,917 people.A blood-protein score statistically accounted for 31.69% of the association between fine-particle pollution and type 2 diabetes in a cohort of 44,917 people.
A standard-deviation rise in the score was linked to a 0.60-unit increase in artery calcium scores on a base-10 logarithmic scale.A standard-deviation rise in the score was linked to a 0.60-unit increase in artery calcium scores on a base-10 logarithmic scale.
A 19-protein score achieved 0.80 versus 0.76 for clinical risk factors alone on a measure of how well it distinguished future heart failure cases.A 19-protein score achieved 0.80 versus 0.76 for clinical risk factors alone on a measure of how well it distinguished future heart failure cases.
A blood-protein model better distinguished who later developed cardiovascular events, scoring 0.730 versus 0.673 for a clinical model in a validation group.A blood-protein model better distinguished who later developed cardiovascular events, scoring 0.730 versus 0.673 for a clinical model in a validation group.
Chronic kidney disease was linked to later metabolic fatty liver disease (hazard ratio 1.36); the reverse link had a ratio of 1.64, versus people without each condition.Chronic kidney disease was linked to later metabolic fatty liver disease (hazard ratio 1.36); the reverse link had a ratio of 1.64, versus people without each condition.
Models built from protein measurements in eight mouse organs tracked age in independent groups but transferred poorly from one organ to another.Models built from protein measurements in eight mouse organs tracked age in independent groups but transferred poorly from one organ to another.
Protein patterns accounted for an estimated 62% of coronary disease risk linked to triglyceride-rich particles and 14% of risk linked to lipoprotein(a).Protein patterns accounted for an estimated 62% of coronary disease risk linked to triglyceride-rich particles and 14% of risk linked to lipoprotein(a).
Who was studied35,269 UK Biobank participants, median 13.7 years
What changedTriglyceride-rich particles and lipoprotein(a) shared 36 proteins; higher scores for both patterns were linked to higher coronary disease risk
The catchThe analyses did not measure whether targeting these proteins prevents coronary disease
Prediction accuracy scores were 0.934 in women and 0.890 in men, on a scale where 1 means perfect ranking of risk.Prediction accuracy scores were 0.934 in women and 0.890 in men, on a scale where 1 means perfect ranking of risk.
In over 36,000 UK Biobank participants, the signature raised Harrell's C-index from 0.798 to 0.862, carrying a hazard ratio of 2.645 per standard deviation increase.In over 36,000 UK Biobank participants, the signature raised Harrell's C-index from 0.798 to 0.862, carrying a hazard ratio of 2.645 per standard deviation increase.