Primordial germ cell population

1. PARP1 decreases primordial germ cell population in human cells.

   “Our identified missense variant (V762A) significantly reduces the germ cell population by enhanced DNA binding resulting in increased apoptosis.”

   CellsV762A missense variantprimordial germ cells

   PARP1 regulates establishment of the ovarian reserve and age at natural menopause

   medRxiv·19 Jun 2025Preprint

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