Polyglutamine aggregates

Biomarker

1 paper1 finding

Model organisms1

Interventions

AA-20

downin model organisms1

1 study

AA-20 decreases polyglutamine aggregates.
“AA-20 reduces polyglutamine aggregation in an autophagy-dependent manner in both human cells and C. elegans”
Model organisms
Autophagy activator AA-20 improves proteostasis and extends Caenorhabditis elegans lifespan
Proceedings of the National Academy of Sciences of the United States of America4 Aug 2025

Latest

3 in 12 months

bioRxiv9 Oct

Low-dose zinc improves health and stress defence in worms

In aged roundworms, a low dose of zinc restored organismal zinc after an approximately 90% drop in zinc-to-sulfur ratio, improving healthspan and stress resistance.In aged roundworms, a low dose of zinc restored organismal zinc after an approximately 90% drop in zinc-to-sulfur ratio, improving healthspan and stress resistance.

Preprint: experiments in wormsInterventions

Paper

Biogerontology19 Sep