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AA-20

Intervention

1 paper5 findings

PubChem 1882724

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: American Diabetes Association and 5 more
  • Model organisms1

Outcomes

4

Autophagy

upin human cells1upin worms1

1 study

  1. AA-20 activates autophagy in human cells.

    “AA-20 that enhances autophagy and lipid droplet clearance in human cells and in the nematode Caenorhabditis elegans.”

    Cells

    Autophagy activator AA-20 improves proteostasis and extends Caenorhabditis elegans lifespan

    Proceedings of the National Academy of Sciences of the United States of America4 Aug 2025

  2. AA-20 activates autophagy in worms.

    “AA-20 that enhances autophagy and lipid droplet clearance in human cells and in the nematode Caenorhabditis elegans.”

    Model organisms

    Autophagy activator AA-20 improves proteostasis and extends Caenorhabditis elegans lifespan

    Proceedings of the National Academy of Sciences of the United States of America4 Aug 2025

More on Autophagy

Fitness

upin worms1

1 study

  1. AA-20 improves fitness in worms.

    “where it also promotes fitness.”

    Model organisms

    Autophagy activator AA-20 improves proteostasis and extends Caenorhabditis elegans lifespan

    Proceedings of the National Academy of Sciences of the United States of America4 Aug 2025

Polyglutamine aggregates

downin model organisms1

1 study

  1. AA-20 decreases polyglutamine aggregates.

    “AA-20 reduces polyglutamine aggregation in an autophagy-dependent manner in both human cells and C. elegans”

    Model organisms

    Autophagy activator AA-20 improves proteostasis and extends Caenorhabditis elegans lifespan

    Proceedings of the National Academy of Sciences of the United States of America4 Aug 2025

More on Polyglutamine aggregates

Lifespan

upin worms1

1 study

  1. AA-20 extends lifespan in worms.

    “we found that AA-20 extends lifespan in WT C. elegans, but not in autophagy-deficient mutants.”

    Model organismsWT

    Autophagy activator AA-20 improves proteostasis and extends Caenorhabditis elegans lifespan

    Proceedings of the National Academy of Sciences of the United States of America4 Aug 2025

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