Polygenic score
Biomarker3 papers2 findings
- Human trial1
- Humans2
Effects
1Discrimination
upin humans1
1 study
Discrimination
upin humans1
Polygenic score improves discrimination in humans.
Reviewtime-dependent discriminationfemales
Response Regarding FRAX Performance Across Race/Ethnicity and Genetic Risk in the Women's Health Initiative · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 12 Sep 2026
Associations
1Osteoporosis
downin humans1
1 study
Osteoporosis
downin humans1
Polygenic score lowers the risk of osteoporosis in humans (0.85, 95% CI: 0.74-0.98).
Humansn = 8,711
Osteoporosis genetic risk prediction using bone mineral density polygenic scores in Japanese: TMM CommCohort study · Journal of human genetics · 9 Sep 2026
Funding
National Institute of Diabetes and Digestive and Kidney DiseasesUS$1.8mNational Human Genome Research InstituteUS$1.2mNational Heart, Lung, and Blood InstituteUS$170.3k7 grants since 2022
National Human Genome Research InstituteEuropean Molecular Biology LaboratoryUS$677.1k2022–2027
Using polygenic scores to improve the prediction of weight loss-associated changes in metabolic risk
National Institute of Diabetes and Digestive and Kidney DiseasesMassachusetts General HospitalUS$842.7k2026–2031
Third Generation Polygenic Score for Chronic Kidney Disease
National Institute of Diabetes and Digestive and Kidney DiseasesColumbia University Health SciencesUS$715.2k2025–2030
National Institute of Diabetes and Digestive and Kidney DiseasesMassachusetts General HospitalUS$123.8k2026–2028
Enabling improved applicability and transferability of polygenic scores across populations
National Human Genome Research InstituteMassachusetts General HospitalUS$536.4k2026–2027
National Institute of Diabetes and Digestive and Kidney DiseasesMassachusetts General HospitalUS$146.9k2022–2027
Advancing the clinical actionability of polygenic scores for coronary artery disease
National Heart, Lung, and Blood InstituteMassachusetts General HospitalUS$170.3k2023–2028
Latest
32Organ age acceleration and mortality risk reflect distinct biological processes
Multi-omics clocks across fourteen organs reveal divergent molecular programs and uncover thirteen candidate genes separating age acceleration from…Multi-omics clocks across fourteen organs reveal divergent molecular programs and uncover thirteen candidate genes separating age acceleration from mortality.