Plasma membrane neuroproteasome abundance

1. APOE is associated with plasma membrane neuroproteasome abundance in cells.

   “Neuroproteasome abundance at the plasma membrane is differentially modulated by ApoE isoforms (E2 > E3 > E4) and declines with age.”

   CellsApoE isoforms E2, E3 and E4neuron

   Neuroproteasomes regulate endogenous tau paired helical filament formation in an APOE genotype- and age-dependent manner

   Nature neuroscience·29 May 2026

More on APOE