Phosphorylated ERK1/2

1. Nicotinamide riboside decreases phosphorylated ERK1/2 in humans.

   “decreases NEV levels of Aβ42, pJNK, and pERK1/2 (kinases involved in insulin resistance and neuroinflammatory pathways).”

   Human trialhealthyoralneuronal-enriched extracellular vesicles500 mg, 2x /day6 weeksn = 22

   Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin

   Aging cell·14 Dec 2022

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1. CD47 increases phosphorylated ERK1/2 in mice.

   “Aortic pERK1/2 was reduced in CD47KO mice despite persistent TSP1 upregulation.”

   Animalsin 5/6 nephrectomy-treated miceaorta

   Thrombospondin 1-CD47 Signalling Modulates Vascular Smooth Muscle Cell Senescence in Chronic Kidney Disease

   International journal of molecular sciences·12 Jan 2026

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