PhenoAge epigenetic age acceleration

Radiographic osteoarthritis progression is associated with PhenoAge epigenetic age acceleration in humans (ΔEAA = 2.1 years).

“Radiographic progressors also exhibited accelerated epigenetic aging using the PhenoAge calculator (ΔEAA = 2.1y, q = 0.02).”

HumansRadiographic osteoarthritis progressors versus non-progressorsperipheral blood2-5 years

Borderline acceleration in blood epigenetic age of unclear biological importance in knee osteoarthritis progression: Specimens and data from the Osteoarthritis Initiative and Johnston County Osteoarthritis Project

Osteoarthritis and cartilage·4 Jun 2025