PhenoAA
3 papers2 findings
- Humans2
- In silico1
Upstream
1Advanced liver fibrosis
no changein humans1
1 study
Advanced liver fibrosis
no changein humans1
Advanced liver fibrosis has no effect on PhenoAA in humans.
“However, no significant association was found between advanced fibrosis and IEAA, PhenoAA, and GrimAA.”
HumansMASLDn = 325
Association between advanced fibrosis and epigenetic age acceleration among individuals with MASLD
Journal of gastroenterology20 Nov 2024
Associations
1Hearing test score
downin humans1
1 study
Hearing test score
downin humans1
PhenoAA is associated with hearing test score in humans (β = -0.081 [95% CI -0.15 to -0.01]).
“Phenotypic age acceleration, GrimAA, and methylation-based pace of aging estimate were significantly associated with lower hearing test scores ( β [95% confidence interval {CI}] = -0.081 [-0.15 to -0.01]”
Humansn = 1,755
Epigenetic Age Acceleration and Hearing Function in US Older Adults
Ear and hearing6 Feb 2026
Latest
6 in 12 monthsGenes
Shared Genetic Architecture Between Epigenetic Aging and Musculoskeletal Diseases
Mendelian randomisation in 788 peopleMusculoskeletal disease
International Journal of Obesity
Epigenetic age acceleration and metabolic syndrome among Hispanic/Latino adults: Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Cohort study of 962 peopleGrimAge
Ear and Hearing
Epigenetic Age Acceleration and Hearing Function in US Older Adults
Cohort study of 1,755 peopleGrimAge
Experimental Gerontology
Bidirectional associations between metabolic syndrome and epigenetic age acceleration: A 20-year longitudinal study in midlife adults
Cohort study of 1,452 peoplePhenoAge
AIDS Research and Human Retroviruses
Epigenetic Age Acceleration and Frailty Among People with HIV
Cross-sectional study of 1,076 peopleGrimAge
GeroScience
Association of muscle mass and strength with blood-based epigenetic aging among middle-aged and older adults in the United States
Cohort study of 1,121 peopleBiomarkers
BMC Medicine
Differential contributions of cardiovascular health-related lifestyle factors to epigenetic ageing: implications for healthy longevity
Cross-sectional study of 1,940 peopleBiomarkers
Biogerontology
Genetic influence of the brain on epigenetic age acceleration: evidence of a large-scale genetic correlation study
Computational studyMechanisms
European Archives of Psychiatry and Clinical Neuroscience
Association between epigenetic age acceleration and psychiatric disorders: a bidirectional Mendelian randomization study
Study in peopleBiomarkers
Brain, Behavior, & Immunity - Health
Depressive symptoms partially mediate the relationship between psychosocial factors and epigenetic age acceleration in a multi-racial/ethnic sample of older adults
Study in peoplePopulations