Periventricular white matter hyperintensities progression
1 finding
Effects
1Total brain volume decline
upin humans1
1 study
Total brain volume decline
upin humans1
Periventricular white matter hyperintensities progression increases total brain volume decline in humans (β=−0.078 [− 0.143 to − 0.012], p = 0.020).
“PWMH progression was associated with faster declines in total brain (β=−0.078 [− 0.143 to − 0.012], p = 0.020) and white matter volumes (β=−0.048 [− 0.092 to − 0.005], p = 0.030).”
Humansbrain2–3 yearsn = 2,496
Alzheimer's research & therapy16 Feb 2026