Periventricular white matter hyperintensities progression

Biomarker

1 finding

Effects

1

Total brain volume decline

upin humans1

1 study
  1. Periventricular white matter hyperintensities progression increases total brain volume decline in humans (β=−0.078 [− 0.143 to − 0.012], p = 0.020).

    “PWMH progression was associated with faster declines in total brain (β=−0.078 [− 0.143 to − 0.012], p = 0.020) and white matter volumes (β=−0.048 [− 0.092 to − 0.005], p = 0.030).”

    Humansbrain2–3 yearsn = 2,496

    Associations of white matter hyperintensity regression and progression with cognitive and structural brain changes: a population-based cohort study

    Alzheimer's research & therapy16 Feb 2026

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