Total brain volume decline

1. Periventricular white matter hyperintensities progression increases total brain volume decline in humans (β=−0.078 [− 0.143 to − 0.012], p = 0.020).

   “PWMH progression was associated with faster declines in total brain (β=−0.078 [− 0.143 to − 0.012], p = 0.020) and white matter volumes (β=−0.048 [− 0.092 to − 0.005], p = 0.030).”

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