In 1,199 adults aged 54–65 without cognitive impairment, an observational study linked these spaces to different factors depending on brain region and sex.In 1,199 adults aged 54–65 without cognitive impairment, an observational study linked these spaces to different factors depending on brain region and sex.
Who was studied1,199 cognitively unimpaired adults
What changedPerivascular space counts differed across brain regions, linking to cardiometabolic factors in centrum semiovale and Alzheimer's markers in hippocampus
The catchHigher genetic risk and lack of cognitive impairment may limit applicability to broader populations
The model scored 0.764 in distinguishing who developed frailty in internal validation, versus 0.747 in a separate Korean cohort.The model scored 0.764 in distinguishing who developed frailty in internal validation, versus 0.747 in a separate Korean cohort.
