European Journal of Pharmacology
Gut microbe products helped metformin protect bone in mice
Experiments in mice with ovaries removed linked the drug’s bone benefits to short-chain fatty acids, small molecules made by gut bacteria.Experiments in mice with ovaries removed linked the drug’s bone benefits to short-chain fatty acids, small molecules made by gut bacteria.
Mouse studyMetformin
Who was studiedMice with ovaries removed
What changedMetformin improved spongy bone structure; lacking receptors for gut microbial fatty acids abolished its benefits
The catchBone microarchitecture was the measure of protection, rather than fractures