Aging Cell
Excess inflammation impaired colon repair in old mice
Experiments monitored mice aged 2–3 and 20–22 months for three weeks after bacterial infection; older animals showed poorer repair of the colon lining.Experiments monitored mice aged 2–3 and 20–22 months for three weeks after bacterial infection; older animals showed poorer repair of the colon lining.
Mouse studyInflammation
Who was studiedYoung and old mice, three weeks, against young mice
What changedAfter infection, about 95% of colon lining pockets were damaged in old mice, compared with about 60% in young mice
The catchInflammatory sensitivity experiments used small-intestine organoids rather than living colons