Number of differentially expressed splicing regulators

1. Caloric restriction increases number of differentially expressed splicing regulators in mice.

   “The number of differentially expressed splicing regulators increased with CR levels in all tissues but primarily the muscle, eWAT, and liver.”

   AnimalsC57BL/6 miceepididymal white adipose tissue, liver, hypothalamus, gastrocnemius muscle, testes, and stomach0–40% calorie restriction at 10% increments3 monthsmales

   A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction

   Life metabolism·11 Feb 2026

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