Non-spike-specific Th1 CD4+ T cell frequency

Biomarker

1 paper1 finding

Humans1

Associations

Older age

downin humans1

1 study

Older age is associated with non-spike-specific Th1 CD4+ T cell frequency in humans.
“older adults showed attenuated responses, including reduced Th1 frequencies in non-spike-specific CD4+ T cells and a higher proportion of central memory cells.”
HumansAfter inactivated SARS-CoV-2 vaccination in adults who had recovered from COVID-19peripheral blood mononuclear cells
Some T cell responses were weaker in older COVID-19 survivors
Journal of translational medicine12 Oct 2026

Latest

1 in 12 months

Journal of Translational Medicine2 h

Some T cell responses were weaker in older COVID-19 survivors

An observational study of COVID-19 survivors aged 18–59 and 60 or older found weaker responses after inactivated vaccines and subsequent Omicron infection in older…An observational study of COVID-19 survivors aged 18–59 and 60 or older found weaker responses after inactivated vaccines and subsequent Omicron infection in older adults.

Cohort study in peopleImmune response

Paper

Non-spike-specific Th1 CD4+ T cell frequency

Associations

Latest

Some T cell responses were weaker in older COVID-19 survivors

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