Non-self multimer binding CD8 T cells

1. Alzheimer's disease decreases non-self multimer binding CD8 T cells in humans (P < 0.015).

   “levels of T cells binding to the non‐self pHLA multimer were significantly diminished in AD irrespective of HLA subtype ( P < 0.015 by 2‐sided T‐Test).”

   Humansirrespective of HLA subtypeblood

   Levels of age‐related blood CD8 T cells binding a non‐self peptide/HLA epitope track with Alzheimer's disease status in HLA‐A2 ⁺ and HLA‐A2 ‐ cohorts: a T cell biomarker assay applicable to all patients

   AAIC 2025 abstract·9 Jan 2026

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1. Non-self multimer binding CD8 T cells predict Alzheimer's disease in humans (AUC 0.878, P < 0.00001).

   “In receiver operating characteristic (ROC) analysis of the HLA‐negative cohort, area under the curve (AUC) was 0.878 for AD ( P < 0.00001) with 79.4% sensitivity and 98.6% specificity”

   Humansin HLA-A2-negative cohortbloodn = 44

   Levels of age‐related blood CD8 T cells binding a non‐self peptide/HLA epitope track with Alzheimer's disease status in HLA‐A2 ⁺ and HLA‐A2 ‐ cohorts: a T cell biomarker assay applicable to all patients

   AAIC 2025 abstract·9 Jan 2026

More on Alzheimer's disease

1. Non-self multimer binding CD8 T cells are associated with APP multimer binding CD8 T cells in humans (r = 0.81, P < 0.001).

   “CD8 T cell binding to a non‐self ( ALIAPVHAV /HLA‐A0201) multimer correlated with APP multimer binding in HLA‐A2‐positive patients (0.42‐0.58x relative to APP/HLA‐A2; r = 0.81; P < 0.001).”

   Humansin HLA-A2-positive subjectsbloodn = 79

   Levels of age‐related blood CD8 T cells binding a non‐self peptide/HLA epitope track with Alzheimer's disease status in HLA‐A2 ⁺ and HLA‐A2 ‐ cohorts: a T cell biomarker assay applicable to all patients

   AAIC 2025 abstract·9 Jan 2026

More on APP multimer binding CD8 T cells