Levels of age‐related blood CD8 T cells binding a non‐self peptide/HLA epitope track with Alzheimer's disease status in HLA‐A2 ⁺ and HLA‐A2 ‐ cohorts: a T cell biomarker assay applicable to all patients

Abstract

Background: We recently developed a CD8 T cell‐induced mouse model that recapitulates definitive hallmarks of Alzheimer's disease (AD) and allowed prediction of previously unknown properties of human sporadic AD (DOI: 10.1073/pnas.2401420121).