Papers on NMNAT2

26 papers

Thursday, September 3

Frontiers in AgingSep 3

A minimal three-arm oral regimen for healthspan: mechanistic alignment with transcriptomic signals from a large parental-lifespan GWAS

Mechanistic alignment of the proposed three-arm oral regimen with transcriptomic signals from a tissue-resolved TWAS of parental lifespan (Timmers et al., 2019 GWAS; n = 1,012,240).

CommentaryInterventions

Paper

Wednesday, July 29

CNS Neuroscience & TherapeuticsJul 29

hUC-MSCs via β-NGF Alleviate Cognitive Impairment After Tibial Fracture Surgery by Regulating the STMN2/NMNAT2-SARM1-NF-κB Signaling Pathway

Experiments in miceBones and joints

Paper

Tuesday, April 7

FigshareApr 7

Tissue-Resolved Transcriptome-Wide Association Study Reveals Targeted NAD⁺ Salvage, Synaptic Refinement, and Reduced Insulin Drive as Transcriptional Mechanisms of Human Lifespan

Preprint: computational studySynapse

Paper

Tuesday, February 18

FASEB JournalFeb 18

Nmnat2 deficiency in the arcuate nucleus or paraventricular nucleus induces Sarm1-independent neuron loss and liraglutide-reversible obesity

Experiments in miceLiraglutide

Paper

Friday, January 17

Cell Death & DiseaseJan 17

Programmed neurite degeneration in human central nervous system neurons driven by changes in NAD⁺ metabolism

Experiments in human cellsNAD+ metabolism

Paper

Tuesday, October 1

Molecular NeurobiologyOct 1

Chronically Low NMNAT2 Expression Causes Sub-lethal SARM1 Activation and Altered Response to Nicotinamide Riboside in Axons

Experiments in miceMechanisms

Paper

Tuesday, April 16

PLOS OneApr 16

Activated NAD+ biosynthesis pathway induces olaparib resistance in BRCA1 knockout pancreatic cancer cells

Experiments in human cellsNAD+ metabolism

Paper

Monday, March 18

Food & FunctionMar 18

β-Nicotinamide mononucleotide supplementation prolongs the lifespan of prematurely aged mice and protects colon function in ageing mice

Experiments in miceNicotinamide mononucleotide

Paper

Sunday, January 28

Molecular NeurodegenerationJan 28

NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport

Experiments in miceGlycolysis

Paper

Friday, December 29

Toxicology and Applied PharmacologyDec 29

NMNATs expression inhibition mediated NAD⁺ deficiency plays a critical role in doxorubicin-induced hepatotoxicity in mice

Experiments in miceNAD+

Paper

Friday, July 28

Antioxidants & Redox SignalingJul 28

NAD⁺, Axonal Maintenance, and Neurological Disease

ReviewMechanisms

Paper

Sunday, January 22

Acta Neuropathologica CommunicationsJan 22

NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve

Study in peopleEye

Paper

Friday, December 16

Biomedicine & PharmacotherapyDec 16

NMNAT2: An important metabolic enzyme affecting the disease progression

ReviewNAD+ metabolism

Paper

Wednesday, June 29

Neurobiology of DiseaseJun 29

Protective effects of NAMPT or MAPK inhibitors and NaR on Wallerian degeneration of mammalian axons

Experiments in cellsInterventions

Paper

Thursday, June 23

Aging CellJun 23

Nicotinamide riboside and caffeine partially restore diminished NAD availability but not altered energy metabolism in Alzheimer's disease

Experiments in human cellsCaffeine

Paper

Wednesday, February 9

bioRxivFeb 9

NAD homeostasis maintained by NMNAT2 supports vesicular glycolysis and fuels fast axonal transport in distal axons of cortical glutamatergic neurons in mice

Preprint: experiments in miceGlycolysis

Paper

Tuesday, December 7

Molecular MetabolismDec 7

Increased glycolysis affects β-cell function and identity in aging and diabetes

Experiments in miceGlycolysis

Paper

Saturday, August 14

Experimental NeurologyAug 14

Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection

Experiments in cellsMechanisms

Paper

Wednesday, April 14

Scientific ReportsApr 14

SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways

Experiments in mouse cellsInterventions

Paper

Tuesday, March 2

NeuronMar 2

SARM1 is a metabolic sensor activated by an increased NMN/NAD⁺ ratio to trigger axon degeneration

Experiments in cellsNAD+ metabolism

Paper

Wednesday, May 27

AntioxidantsMay 27

Caffeine and NAD⁺ Improve Motor Neural Integrity of Dissociated Wobbler Cells In Vitro

Experiments in mouse cellsNAD+

Paper

Friday, January 31

Experimental NeurologyJan 31

Evaluation of the NAD⁺ biosynthetic pathway in ALS patients and effect of modulating NAD⁺ levels in hSOD1-linked ALS mouse models

Study in peopleAmyotrophic lateral sclerosis

Paper

Tuesday, March 26

Aging CellMar 26

NMNAT2-mediated NAD⁺ generation is essential for quality control of aged oocytes

Experiments in miceMechanisms

Paper

Friday, February 1

Human Molecular GeneticsFeb 1

Low levels of NMNAT2 compromise axon development and survival

Experiments in miceMechanisms

Paper

Wednesday, December 7

PreprintDec 7

PLOS Science Wednesday: Hi reddit, we’re Hui-Chen Lu, Yousuf Ali, Hunter Allen and we found that people with the NMNAT2 protein had greater resistance to cognitive decline – Ask Us Anything!

Preprint: commentaryMechanisms

Paper

Friday, October 17

Cell Death and DifferentiationOct 17

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

Experiments in cellsMechanisms

Paper