Natural antibodies

2 papers study it14 more mention it3 findings

Animals1

Associations

3

Neurodegenerative disease

upin humans1

1 study

Natural antibodies are associated with neurodegenerative disease in humans.
“age-dependent loss of function of NAbs has been associated with clinically-relevant diseases in the elderly, such as atherosclerosis and neurodegenerative disorders.”
Review
The immunology of B-1 cells: from development to aging
Immunity & ageing : I & AAug 2, 2024

More on Neurodegenerative disease

Atherosclerosis

upin humans1

1 study

Natural antibodies are associated with atherosclerosis in humans.
“age-dependent loss of function of NAbs has been associated with clinically-relevant diseases in the elderly, such as atherosclerosis and neurodegenerative disorders.”
Review
The immunology of B-1 cells: from development to aging
Immunity & ageing : I & AAug 2, 2024

More on Atherosclerosis

Age

upin M. coronatus1

1 study

Age predicts natural antibodies in M. coronatus.
“By contrast, age predicted the levels of NAbs and HL ratio”
Animals
Telomere length declines with age, but relates to immune function independent of age in a wild passerine
Royal Society open scienceApr 27, 2022

Funding

2 grants since 2019

Veterans AffairsNational Institute of Allergy and Infectious DiseasesUS$1.1m

Latest

3 papers in 12 months

Frontiers in ImmunologyOct 13

Complement system in kidney transplantation: from innate immune surveillance to a therapeutic and genetic engineering target

ReviewComplement system

Immunological ReviewsAug 24

B1 Cells for Life

ReviewMechanisms

Current Opinion in LipidologyAug 13

Lipids and lipoproteins in calcific aortic valve disease

ReviewMechanisms

Immunity & AgeingFeb 25

Secreted IgM deficiency alters the retinal landscape enhancing neurodegeneration associated with aging

Experiments in miceEye

Immunity & AgeingAug 3

The immunology of B-1 cells: from development to aging

ReviewMechanisms

Science AdvancesMay 12

Broad responses to chemical adducts shape the natural antibody repertoire in early infancy

Cohort study in peopleImmune response

Immunity & AgeingMar 10

Sex-specific innate immunity and ageing in long-lived fresh water turtles (Kinosternon flavescens: Kinosternidae)

Experiments in animalsBlood and immune system

Frontiers in ImmunologyJan 31

Age-related changes in antigen-specific natural antibodies are influenced by sex

Experiments in miceMechanisms

Experimental GerontologyJul 23

Immunophenotypic characterization of B1a lymphocytes in Cuban older adults

Cross-sectional study of 30 peopleMechanisms

Royal Society Open ScienceMay 24

Telomere length declines with age, but relates to immune function independent of age in a wild passerine

Experiments in animalsTelomerase and telomere maintenance