Naïve CD4+ T cell percentage

1. Frailty is associated with naïve CD4+ T cell percentage in humans.

   “In frail individuals, the proportions of CD4 and CD8 T cells with a naïve phenotype were significantly reduced”

   Humansin people with HIV

   Frailty in People with HIV Is Linked to Inflammation, Bone Health, and T-Cell Exhaustion

   The Journal of infectious diseases·Feb 6, 2026

1. PBMC mitochondrial respiration is associated with naïve CD4+ T cell percentage in humans.

   “We found positive associations between basal and maximal MRPBMC, and the percentage of CD4+ T cells, with a notable link to naïve CD4+ T cells (p < 0.05).”

   Humanshealthy, physically activePBMCsn = 16

   PBMCs Mitochondrial Respiration and Its Relation to Immunity, Fitness, and Metabolic Risk in the Healthy Elderly

   Journal of cellular physiology·Sep 1, 2025

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1. Purpose in life is associated with naïve CD4+ T cell percentage in humans (+0.9% (95% CI 0.5%, 1.3%) per 1-SD increment).

   “A 1-SD increment in purpose in life was associated with the percentage of naïve CD4+ T cells increasing by 0.9 (95%CI 0.5%, 1.3%)”

   Humansn = 7,870

   Relations of optimism and purpose in life to immune markers in aging

   Journal of psychosomatic research·Jun 22, 2024

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1. Optimism is associated with naïve CD4+ T cell percentage in humans (+0.6% (95% CI 0.2%, 1.0%) per 1-SD increment).

   “a 1-SD increment in optimism was associated with the percentage of naïve CD4+ T cells increasing by 0.6 (95%CI 0.2%, 1.0%).”

   Humansn = 7,870

   Relations of optimism and purpose in life to immune markers in aging

   Journal of psychosomatic research·Jun 22, 2024

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