Naïve CD4+ T cell count

1. TNFR1 mediates naïve CD4+ T cell count in humans (10% and 5% mediated).

   “TNFR1, a key marker of inflammaging, mediated 10% and 5% of the age-related declines in naïve CD4T and CD8T cells respectively in the HRS (n = 8,261).”

   Humansn = 8,261

   Evidence for an energetic trade-off model linking inflammaging and immunosenescence in the US Health and Retirement Study and UK Biobank

   bioRxiv : the preprint server for biology·17 Oct 2025Preprint

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