Morphometrics

Biomarker

1 paper

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Research Square

Probiotics linked to brain surface area changes in older adults

Surface area in one brain region increased by 21.53 square millimetres with probiotics, against a fall of 54.39 square millimetres with placebo over 52 weeks.Surface area in one brain region increased by 21.53 square millimetres with probiotics, against a fall of 54.39 square millimetres with placebo over 52 weeks.

Preprint: randomised trial in 68 older adults with early cognitive impairment, 52 weeks, against placeboProbiotics

Limit: Excluding participants without repeat, analyzable MRI could bias the comparison

European Radiology

Silent spinal fractures were common in UK Biobank adults

Scans identified moderate or severe spinal fractures in 14.6% of 2,446 symptom-free UK Biobank participants aged 40–79, including people with normal bone density.Scans identified moderate or severe spinal fractures in 14.6% of 2,446 symptom-free UK Biobank participants aged 40–79, including people with normal bone density.

Cross-sectional study of 2,446 asymptomatic UK Biobank participantsBones and joints

Limit: Vertebral deformities could be misclassified as fractures without an external reference standard

medRxiv

Spinal cord charts map age patterns and disease differences

Different upper spinal cord measurements peaked at ages 29.7–44.1 years in reference charts based on scans of 10,159 healthy people aged 8–85.Different upper spinal cord measurements peaked at ages 29.7–44.1 years in reference charts based on scans of 10,159 healthy people aged 8–85.

Preprint: cross-sectional study of 10,159 peopleBiomarkers
Brain Imaging and Behavior

High blood pressure duration linked to brain tissue differences

A cross-sectional study of 487 people with high blood pressure and 165 controls found region-specific differences in grey matter volume across disease-duration groups.A cross-sectional study of 487 people with high blood pressure and 165 controls found region-specific differences in grey matter volume across disease-duration groups.

Cross-sectional study of 487 peoplePopulations
Psychological Medicine

Brain age estimates were higher across six disorders

The gap between scan-estimated and actual age exceeded age-matched controls by 7.64 years in schizophrenia and 7.61 years in frontotemporal dementia.The gap between scan-estimated and actual age exceeded age-matched controls by 7.64 years in schizophrenia and 7.61 years in frontotemporal dementia.

Case-control study of 25,425 peopleBiomarkers