Papers on molecular markers

327 papers20 new in 30 days

Friday, December 20

Stem CellsDec 20

Genetic ablation of p16 mitigates premature osteoporosis induced by PTHrP nuclear localization sequence and C-terminal deletion through inhibition of cellular senescence

Experiments in miceCellular senescence

Paper

Tuesday, December 17

FoodsDec 17

In Vivo and In Vitro Studies Assessing the Safety of Monosodium Glutamate

Experiments in fliesInterventions

Paper

Thursday, December 12

BiomedicinesDec 12

Comparative Analysis of Extracorporeal Shockwave Therapy, Bisphosphonate, and Wharton Jelly-Derived Mesenchymal Stem Cells in Preserving Bone and Cartilage Integrity and Modulating IL31, IL33, and BMP2 in the Cartilage of Ovariectomized Rat Model

Experiments in ratsBones and joints

Paper

Wednesday, December 4

Cell Death and DifferentiationDec 4

HRK downregulation and augmented BCL-xL binding to BAK confer apoptotic protection to therapy-induced senescent melanoma cells

Experiments in human cellsCellular senescence

Paper

Monday, December 2

Aging CellDec 2

Tissue-specific methylomic responses to a lifestyle intervention in older adults associate with metabolic and physiological health improvements

Non-randomized trial in peopleInterventions

Paper

Monday, November 25

Journal of Cellular and Molecular MedicineNov 25

iPSCs-derived iMSCs prevent osteoporotic bone loss and affect bone metabolites in ovariectomized mice

Experiments in miceOsteoporosis

Paper

Thursday, November 21

Pflugers ArchivNov 21

Estrogen hindrance escalates inflammation and neurodegeneration in the hippocampal regions of collagen-induced arthritis female Sprague-Dawley rats

Experiments in ratsInflammation

Paper

Monday, November 18

bioRxivNov 18

Leveraging Single-Cell RNA-Seq to Generate Robust Microglia Aging Clocks

Preprint: computational studyBiomarkers

Paper

Wednesday, October 30

bioRxivOct 30

Markers, Mechanisms and Metrics of Biological Aging: A Scoping Review

Preprint: systematic reviewBiomarkers

Paper

Tuesday, October 29

PNASOct 29

Cellular heterogeneity and dynamics of the human uterus in healthy premenopausal women

Study in peopleAI & data

Paper

Thursday, October 10

Scientific ReportsOct 10

Clinical vs. chronological skin age: exploring determinants and stratum corneum protein markers of differential skin ageing in 351 healthy women

Cohort study of 360 peopleBiomarkers

Paper

Tuesday, October 1

GerontologyOct 1

Healthy Aging at Moderate Altitudes: Hypoxia and Hormesis

ReviewHypoxia and HIF signaling

Paper

Saturday, September 14

CellsSep 14

Phospholipid Phosphatase 3 (PLPP3) Induces Oxidative Stress to Accelerate Ovarian Aging in Pigs

Experiments in pigsOxidative stress and ROS signaling

Paper

Wednesday, September 11

Science AdvancesSep 11

Reproductive aging weakens offspring survival and constrains the telomerase response to herpesvirus in Pacific oysters

Experiments in model organismsTelomerase and telomere maintenance

Paper

Wednesday, August 28

Aging CellAug 28

Premature cognitive decline in a mouse model of tuberous sclerosis

Experiments in miceInterventions

Paper

Thursday, August 22

PLOS OneAug 22

Bartonella spp. infection in people with Mild Cognitive Impairment: A pilot study

Case-control study in peopleMild cognitive impairment

Paper

Thursday, August 15

Nature AgingAug 15

Nonlinear dynamics of multi-omics profiles during human aging

Cohort study of 108 peopleMechanisms

Paper

medRxivAug 15

Persistent obesity since childhood or adolescence accelerates biological aging in young adults from Chile’s oldest birth cohort

Preprint: cohort study in peopleObesity

Paper

Monday, July 29

Frontiers in GeneticsJul 29

A cross-tissue transcriptome-wide association study identifies new susceptibility genes for frailty

Computational studyMechanisms

Paper

International ImmunopharmacologyJul 29

91 Circulating inflammatory proteins and the risk of age-related macular degeneration: A bidirectional Mendelian randomization study

Mendelian randomization in peopleInflammation

Paper

Sunday, July 28

Experimental GerontologyJul 28

Contribution of impaired autophagy, mitochondrial dysfunction and abnormal lipolysis to epididymal aging in mice

Experiments in miceAutophagy

Paper

Monday, July 15

bioRxivJul 15

qMAP enabled microanatomical mapping of human skin aging

Preprint: cross-sectional study of 99 peopleBiomarkers

Paper

Sunday, July 7

Archives of Gerontology and GeriatricsJul 7

Pleiotropic effects on Sarcopenia subphenotypes point to potential molecular markers for the disease

Computational studySarcopenia

Paper

Sunday, June 30

Cellular SignallingJun 30

POSTN promotes nucleus pulposus cell senescence and extracellular matrix metabolism via activing Wnt/β-catenin and NF-κB signal pathway in intervertebral disc degeneration

Experiments in ratsWnt/β-catenin signaling

Paper

Tuesday, June 11

In Vitro Cellular & Developmental Biology AnimalJun 11

Integrated bioinformatics and validation reveal PTGS2 and its related molecules to alleviate TNF-α-induced endothelial senescence

Experiments in human cellsInterventions

Paper

Friday, June 7

Experimental Cell ResearchJun 7

Multi-omics reveals the role of MCM2 and hnRNP K phosphorylation in mouse renal aging through genomic instability

Experiments in miceDNA damage response

Paper

Saturday, May 25

GeroScienceMay 25

Self-rated health, epigenetic ageing, and long-term mortality in older Australians

Cohort study of 1,059 peopleSelf-rated health

Paper

Thursday, May 9

eLifeMay 9

Two long-axis dimensions of hippocampal-cortical integration support memory function across the adult lifespan

Preprint: cross-sectional study in peopleMechanisms

Paper

Sunday, April 28

Journal of Cancer SurvivorshipApr 28

Determining the relationship of p16INK4a and additional molecular markers of aging with clinical frailty in hematologic malignancy

Cohort study of 70 peoplep16INK4a

Paper

Tuesday, April 23

Clinical ProteomicsApr 23

Multiplex proteomics identifies inflammation-related plasma biomarkers for aging and cardio-metabolic disorders

Cross-sectional study of 30 peopleBiomarkers

Paper