MK6240 tau PET

1. MK6240 tau PET is associated with cognitive score in humans.

   “The discordant groups present higher Centiloid than the ptau217‐/Tau‐ group and overall decreased scores in cognitive tests, except for p ‐tau217+/MK6240‐ group”

   Humansin discordant biomarker groups compared to ptau217-/Tau- group

   Head‐to‐head trajectories of MK6240, Flortaucipir, and plasma p ‐tau217 as a function of Aβ

   AAIC 2025 abstract·23 Dec 2025

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1. Aβ-PET is associated with MK6240 tau PET in humans (22 Centiloids).

   “Among the tested markers, MK6240 was the earliest to show abnormality as a function of Centiloid, occurring at 22 Centiloids, followed by plasma p ‐tau217 at 38 Centiloid and Flortaucipir at Centiloid 56”

   Humansas a function of Aβ burden (Centiloids)

   Head‐to‐head trajectories of MK6240, Flortaucipir, and plasma p ‐tau217 as a function of Aβ

   AAIC 2025 abstract·23 Dec 2025

More on Aβ-PET