Targeting pre‐symptomatic AD individuals: Deep cognitive assessment and plasma biomarkers to predict tau aggregation

AAIC 2025 Abstract

Abstract

Background: Cognitively unimpaired (CU) individuals with both elevated brain amyloid load and tau burden in the medial temporal (MTL) and temporal neocortex (NEO) face high risk of short‐term cognitive decline (≤5 years; risk=50%).

The paper