MIF expression

1. Fisetin decreases MIF expression in humans.

   “Bolus dose also significantly reduced macrophage migration inhibition factor (MIF) and alpha-L-fucosidase 1 (FUCA1) compared to baseline and decreased MIF compared to daily dose.”

   Human trialBolus dosing compared with baseline and daily dosingperipheral blood mononuclear cell20 mg/kg for two consecutive days on and 28 days off45 daysn = 40

   Effects of Two Fisetin Dosing Regimens on Reducing Senescence-Related Genes in Peripheral Blood Mononuclear Cells in Aged Humans

   Preprints.org·22 Jul 2026Preprint

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